Name: Fmoc-N-amido-PEG5-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Appearance

Colorless to yellow viscous liquid

Storage

Store at 2-8°C

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Fmoc-N-amido-PEG5-acid; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid; Fmoc-NH-PEG5-CH2CH2COOH; 5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester; 2,7,10,13,16,19-Hexaoxa-4-azadocosan-22-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-; Fmoc-PEG5-propionic acid

Boiling Point

711.4±60.0 °C at 760 mmHg

Density

1.210±0.06 g/cm3 at 20°C, 760 Torr

InChI Key

TWQTXZPTZPOEEB-UHFFFAOYSA-N

InChI

InChI=1S/C28H37NO9/c30-27(31)9-11-33-13-15-35-17-19-37-20-18-36-16-14-34-12-10-29-28(32)38-21-26-24-7-3-1-5-22(24)23-6-2-4-8-25(23)26/h1-8,26H,9-21H2,(H,29,32)(H,30,31)

SMILES

C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCCC(=O)O

Fmoc-N-amido-PEG5-propionic acid, provides a polyethylene glycol based spacer with an amide-bearing handle and an Fmoc-protected functionality for controlled conjugation. Its flexible, hydrophilic architecture can help tune degrader solubility and the effective distance between ligand warheads in targeted protein degradation workflows. The points below describe the structure and practical reactivity for assembling PROTAC constructs.

Structure: The linker contains an Fmoc-protected amide functionality, a PEG-based ether-rich chain, and a terminal carboxylic acid suitable for coupling. It features stable covalent amide and ether linkages, with conformational flexibility that supports aqueous compatibility and reduced steric constraints in conjugates.

Reactivity: The terminal carboxylic acid can be activated for peptide-style bond formation with amine-bearing ligands or activated intermediates, commonly using carbodiimide coupling chemistry with suitable additives. The Fmoc group enables orthogonal protection strategies; it is typically removed under base conditions to expose an amine for subsequent coupling. Reaction design should consider maintaining PEG integrity and minimizing side reactions during activation and deprotection steps.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂