INY-03-041 trihydrochloride is an effective and highly selective PROTAC-based pan-AKT degrader. It is composed of ATP-competitive AKT inhibitor Ipatasertib and Lenalidomide (a Cereblon ligand). It inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively.
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