TL13-12 - CAS 2229037-04-9

TL13-12 is a potent PROTAC® degrader targeting anaplastic lymphoma kinase (ALK) with an IC50 value of 0.69 nM, consisiting of a cereblon E3 ligase ligand Pomalidomide conjugated to an ALK inhibitor by a linker.

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Molecular Formula
C₄₅H₅₃ClN₁₀O₁₀S
Molecular Weight
961.48

TL13-12

    • Specification
      • Purity
        ≥98% by HPLC
        Synonyms
        N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
        Storage
        Store at -20°C
        Shipping
        Room temperature in continental US; may vary elsewhere.
    • Properties
      • InChI Key
        WXNUIPVZMJMPNM-UHFFFAOYSA-N
        InChI
        1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-21-15-47-39(58)27-48-34-9-6-7-30-40(34)44(61)56(43(30)60)35-13-14-38(57)52-42(35)59/h4-12,25-26,28,35,48H,13-24,27H2,1-3H3,(H,47,58)(H,52,57,59)(H2,49,50,51,53)
        Canonical SMILES
        COC1=C(C=CC(N2CCN(CC2)CCOCCOCCNC(CNC3=C4C(N(C(C4=CC=C3)=O)C5CCC(NC5=O)=O)=O)=O)=C1)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl
        Pub Chem ID
        138108740
    • Preparing Stock Solutions
      • ConcentrationVolumeMass1 mg5 mg10 mg
        1 mM1.04 mL5.2 mL10.4 mL
        5 mM0.21 mL1.04 mL2.08 mL
        10 mM0.1 mL0.52 mL1.04 mL
        50 mM0.02 mL0.1 mL0.21 mL
Bio Calculators
Stock concentration: *
Desired final volume: *
Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
g/mol
g

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