Mal-NH-PEG24-CH2CH2COOPFP ester
Cat No.: BP-502114
4.5 
Mal-NH-PEG24-CH2CH2COOPFP ester is a heterobifunctional PEG-based PROTAC linker featuring a maleimide group for selective conjugation to thiols and a terminal activated ester (O-alkyl fluorophenyl ester) designed for acylation of primary amines. Structurally, it comprises a long, flexible poly(ethylene glycol) chain that spaces the two reactive ends, with an ethylene glycol–like segment and a propyl/alkyl spacer that supports productive geometry for ternary-complex formation in targeted protein degradation constructs. In PROTAC design, the maleimide enables site-specific attachment to cysteine-containing ligands or engineered proteins, while the activated ester facilitates coupling to amine-bearing partners such as lysine-functionalized targeting modules, thereby connecting the E3 ligase recruiter and the target-binding moiety through a stable amide linkage. This linker value lies in its ability to improve solubility, reduce steric hindrance, and provide modular, orthogonal conjugation chemistry for building and optimizing degradation reagents.
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker is designed to provide a flexible, hydrophilic PEG-based spacer that can connect a targeting ligand to an E3-ligase-recruiting module, supporting productive ternary complex formation and efficient targeted protein degradation. Its ether-rich PEG architecture promotes aqueous solubility and reduces non-specific hydrophobic interactions, while the terminal reactive handle enables conjugation under standard bioconjugation conditions. The following sections describe the linker’s structure and the practical considerations for assembling PROTACs using this reagent.
Structure: The linker contains a polyethylene glycol segment with repeating ether linkages, providing conformational flexibility and strong water compatibility. A terminal ester functionality and an ethyl/alkyl spacer motif support stable covalent attachment to partner fragments. Overall, it presents a polar, ether-rich backbone with an electrophilic ester site for derivatization.
Reactivity: The ester group is suitable for nucleophilic acyl substitution or related coupling strategies commonly used in PROTAC synthesis, where a nucleophile from the partner ligand replaces the leaving group to form a new amide or related linkage. Typical approaches use mild base or nucleophilic activation, with polar organic solvents or mixed aqueous/organic systems to maintain PEG solubility. Reaction progress is monitored by analytical methods such as LC-MS or HPLC, and purification is performed to remove unreacted starting materials.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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