m-PEG49-acid
Cat No.: BP-502116
4.5 
m-PEG49-acid is a monodisperse, meta-anchored polyethylene glycol (PEG) linker terminated with a carboxylic acid, providing a flexible, hydrophilic chain for conjugation chemistry in targeted protein degradation constructs. The PEG backbone acts as a spacer that can reduce steric interference between the two binding partners of a PROTAC, while the terminal acid enables reliable coupling to ligands or linker fragments through standard amide-forming reactions (e.g., via activated carboxyl derivatives). In PROTAC design, this type of linker supports productive ternary complex formation by improving solubility, maintaining conformational freedom, and allowing tuning of the effective distance and orientation between the target-binding moiety and the E3 ligase recruiter. Its long, flexible architecture is particularly valuable when optimizing degradation potency and selectivity across linker-length and attachment-position variants, facilitating systematic structure–activity relationship studies in targeted degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG49-acid is a polyethylene glycol-based PROTAC linker acid designed to provide a hydrophilic, conformationally flexible spacer between a ligand and an E3-recruiting or target-binding module. Its ether-rich PEG scaffold helps improve solubility and can reduce steric clashes, supporting efficient ternary complex formation in targeted protein degradation workflows. The points below describe its structure and practical reactivity considerations for PROTAC assembly.
Structure: The linker consists of a PEG backbone terminated with a carboxylic acid, featuring repeating ether linkages that confer flexibility and strong hydrogen-bonding capability. The acid functionality enables stable amide or ester formation, while the PEG segment imparts high polarity and water compatibility.
Reactivity: As a carboxylic acid, it is typically activated for coupling to amine-bearing partners using standard peptide-coupling chemistries (e.g., carbodiimide-based systems with additives) to form amide bonds. Alternatively, conversion to an activated ester can support nucleophilic acyl substitution. Reactions are commonly performed in polar aprotic solvents under conditions that preserve PEG integrity and minimize side reactions such as hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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