ITM2B (Integral Membrane Protein 2B)

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ITM2B (Integral Membrane Protein 2B) is a protein encoded by the ITM2B gene in the human body. ITM2B or BRI2 is a gene located on chromosome 13. The gene encodes a transmembrane protein, which is processed at the C-terminal of furin or furin-like proteases to produce secreted small peptides, thus inhibiting the deposition of β-amyloid protein. Mutations in the size of the peptide that causes the C-terminal extension of the protein to increase secretion are associated with two neurogenic diseases, familial British dementia, and familial Danish dementia. Diseases associated with ITM2B include retinal dystrophy, retinal dysfunction, and ganglion cell abnormalities, and cerebral amyloid angiopathy.

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