Bis-PEG9-acetic acid
CAS No.: 2250056-46-1
Cat No.: BP-500363
Purity: >95%
4.5 
Bis-PEG9-acetic acid is a bifunctional polyethylene glycol (PEG) linker featuring two terminal acetic acid groups separated by PEG9 chains, providing a flexible, hydrophilic spacer suitable for conjugation chemistry. Structurally, it presents a long, solvated polymeric backbone that can reduce steric congestion and help maintain productive geometry between a ligand moiety and an E3-recruiting or target-binding component in PROTAC constructs. In targeted protein degradation designs, such PEG-based linkers act as molecular “tethers,” improving solubility and enabling controlled spatial presentation of two binding partners so that ternary complex formation and subsequent ubiquitin-mediated degradation can proceed efficiently. Its two carboxyl termini facilitate amide or ester coupling to other PROTAC fragments, supporting modular synthesis and systematic linker optimization. As a research reagent, it is valuable for generating PROTAC analog libraries to probe how linker length, flexibility, and hydrophilicity influence binding, cellular uptake, and degradation potency.
Structure of 2250056-46-1
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Bis-PEG9-acetic acid is a polyethylene glycol (PEG)-based bifunctional linker designed to support targeted protein degradation (PROTAC) workflows by providing flexible spacing and solubilizing character between a ligand and an E3-recruiting module. Its two carboxylic acid termini enable robust conjugation strategies that help maintain productive linker geometry and aqueous compatibility. The following sections describe its structural features and practical reactivity considerations for PROTAC assembly in detail below.
Structure: Bis-PEG9-acetic acid is a PEG-containing biscarboxylic acid featuring an ether-rich polymer backbone that confers conformational flexibility. It contains two terminal acetic acid functional groups suitable for amide or ester formation. The molecule’s ether linkages and carboxyl groups support strong hydrogen-bonding and aqueous solubility.
Reactivity: The carboxylic acids are typically activated for PROTAC coupling via standard carboxyl activation chemistries, enabling amide bond formation with amine-bearing ligands under mild base conditions. Common activation approaches include carbodiimide-mediated coupling and acid-activating reagents, often in polar aprotic solvents with controlled pH to minimize side reactions. The flexible PEG scaffold generally stabilizes conjugation efficiency and improves handling during stepwise synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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