BnO-PEG1-CH2COOH
CAS No.: 93206-09-8
Cat No.: BP-501272
4.5 
BnO-PEG1-CH2COOH is a benzyl-ether terminated, short polyethylene glycol linker bearing a terminal acetic acid functionality, providing a compact, water-compatible tether suitable for PROTAC synthesis. Structurally, it contains a benzyl oxy group at one end and a carboxymethyl group at the other, enabling straightforward coupling to ligands through amide or ester-forming chemistries while maintaining a defined linker length and flexibility. In PROTAC architectures, such PEG-based linkers help position the two binding elements to favor productive formation of the ternary complex between the target protein ligand and the E3 ligase recruiter, while also improving solubility and reducing non-specific hydrophobic interactions. As a practical building block, BnO-PEG1-CH2COOH supports systematic linker optimization, allowing researchers to tune spatial arrangement and physicochemical properties to enhance degradation efficiency and experimental reproducibility in targeted protein degradation studies.
Structure of 93206-09-8
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* For research and manufacturing use only. Not for human or clinical use.
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BnO-PEG1-CH2COOH is a PEG-based linker designed for assembling PROTACs, providing a flexible, water-compatible spacer that can improve effective reach between a target-binding ligand and an E3 ligase ligand. Its ether-rich backbone and terminal carboxylic acid enable robust conjugation strategies commonly used in targeted protein degradation workflows. The detailed structure and reactivity considerations are provided below.
Structure: The linker contains a benzyl ether (BnO) group connected to a short polyethylene glycol segment and terminates in a primary carboxylic acid. It features ether linkages and a flexible polyether chain, with a polar, hydrogen-bonding functional group that supports solubility and conformational adaptability.
Reactivity: The terminal carboxylic acid is suitable for amide-bond formation with amine-functionalized ligands under standard coupling conditions. Typical approaches use carboxyl-activation reagents (e.g., carbodiimide-type systems) in compatible polar solvents, often with base to promote nucleophilic acyl substitution. For PROTAC assembly, the linker is generally coupled to one ligand first, then the second ligand is attached through orthogonal functional handles when present.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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