m-PEG24-azide
Cat No.: BP-501937
4.5 
m-PEG24-azide is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal azide group, designed for modular conjugation in targeted protein degradation workflows. Structurally, it consists of a PEG chain of intermediate length that provides aqueous solubility and conformational flexibility, capped at one end with a methoxy group and functionalized at the other end with an azide handle for bioorthogonal coupling. In PROTAC construction, the azide enables efficient attachment to complementary alkyne-bearing partners (e.g., via copper-catalyzed or strain-promoted azide–alkyne cycloaddition), allowing researchers to tune the spatial relationship between an E3-ligand moiety and a target-binding ligand. This linker strategy can improve effective ternary complex formation by reducing steric clashes and maintaining favorable linker reach. As a result, m-PEG24-azide is a practical reagent for assembling and optimizing degraders, facilitating systematic structure–activity studies while maintaining compatibility with aqueous experimental conditions.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG24-azide is a polyethylene glycol (PEG)-based linker bearing a terminal azide group, designed for modular assembly of PROTACs and other targeted protein degradation constructs. Its PEG scaffold provides conformational flexibility and improved solubility, while the azide handle enables reliable bioorthogonal conjugation to complementary functional groups. This combination supports efficient synthesis of degraders and facilitates downstream characterization and optimization. Detailed structural and reactivity considerations are provided below.
Structure: The linker consists of an ether-rich PEG backbone terminated by an azide functional group. It features multiple C–O bonds typical of PEG, with an N3 moiety at the terminus. The resulting amphiphilic, flexible, and water-compatible architecture supports linker-mediated spacing and reduced aggregation.
Reactivity: The azide group is commonly used in copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkene/alkyne conjugation to form stable triazole or related linkages. Typical PROTAC synthesis employs an orthogonal coupling partner bearing a complementary alkyne/alkene, with appropriate catalysts (for copper-mediated routes) or catalyst-free conditions (for strained partners). Solvent systems are selected to maintain solubility of PEG conjugates and minimize side reactions, following standard click-chemistry practices.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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