HQ461

 CAS No.: 1226443-41-9  Cat No.: BP-900074 4.5  

HQ461 is a molecular glue that enhances CDK12-DDB1 interaction, triggering cyclin K degradation. This results in impaired CDK12 function, decreased phosphorylation of CDK12 substrates, downregulation of DNA damage response genes, and cell death.

HQ461

Structure of 1226443-41-9

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Molecular Glue
Molecular Formula
C15H15N5OS2
Molecular Weight
345.44
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Historical Records: Amino-PEG3-amine | Cytochalasin J | 2-Bromoethyl ether | Pomalidomide-linker 1 | Tos-PEG4-THP | FPFT-2216 | Biotin-PEG6-Thalidomide | Asukamycin | Lenalidomide-d5 | E 7820 | HQ461

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