Hydroxy-PEG10-propionic acid
CAS No.: 2375611-66-6
Cat No.: BP-500944
Purity: >98%
4.5 
Hydroxy-PEG10-propionic acid is a PEG-based linker building block featuring a terminal hydroxyl group and a terminal propionic acid functionality, providing a flexible, hydrophilic spacer of approximately ten ethylene glycol units. The hydroxyl end can be used for controlled derivatization or coupling strategies, while the carboxylic acid end enables amide or ester formation with complementary PROTAC warhead or ligand handles. In PROTAC design, such PEG spacers are widely used to tune linker length, conformational freedom, and solvent exposure, which can improve productive orientation between the target-binding ligand and the E3 ligase recruiter, thereby supporting efficient ternary complex formation. Its flexible, water-compatible character also helps reduce steric clashes and can enhance overall solubility of conjugates, facilitating synthesis and downstream biological evaluation. As a result, Hydroxy-PEG10-propionic acid is a practical reagent for generating modular targeted degradation constructs and for systematic linker optimization in structure–activity studies.
Structure of 2375611-66-6
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Hydroxy-PEG10-propionic acid is a polyethylene glycol-based linker designed to support PROTAC assembly by providing a hydrophilic, flexible spacer that can improve solubility and help tune the effective distance between a targeting ligand and an E3 ligase recruiter. Its terminal hydroxy functionality and carboxylic acid handle enable robust conjugation strategies commonly used in targeted protein degradation workflows. Detailed structural and synthetic considerations are provided below.
Structure: The linker comprises a PEG chain terminated by a hydroxy group and a propionic acid moiety. It contains repeating ether linkages along the polymer backbone, with a terminal carboxylic acid and an alcohol. These features confer strong hydrogen-bonding capacity, high polarity, and water-compatible physicochemical behavior.
Reactivity: The carboxylic acid can be activated for amide-bond formation (for example, using standard coupling chemistries such as carbodiimide-based systems with an appropriate additive), enabling attachment to amine-bearing ligands. The terminal hydroxy group can be converted to leaving-group derivatives or employed in ether-forming conjugations under dehydrating or activating conditions. Conjugations are typically performed in polar aprotic solvents with inert atmosphere when needed to suppress side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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