Hydroxy-PEG20-Boc
Cat No.: BP-501803
4.5 
Hydroxy-PEG20-Boc is a polyethylene glycol (PEG) linker bearing a terminal hydroxyl group and a Boc-protected functionality, providing a flexible, hydrophilic chain of approximately twenty ethylene glycol units for controlled spacing in PROTAC architectures. The PEG segment enhances aqueous solubility and can reduce steric interference between the targeting ligand and the E3 ligase–recruiting moiety, while the terminal hydroxyl enables straightforward conjugation or further derivatization through standard coupling chemistry. The Boc group serves as a protected handle for subsequent deprotection and functional group installation, allowing researchers to tune the attachment point and optimize linker length, polarity, and conformational freedom. In targeted protein degradation research, such PEG-based linkers are widely used to modulate effective ternary complex formation and degradation potency by balancing flexibility with productive geometry. This product is therefore a practical building block for constructing and systematically evaluating next-generation PROTACs and related bifunctional degraders.
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* For research and manufacturing use only. Not for human or clinical use.
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Hydroxy-PEG20-Boc is a polyethylene glycol–based linker bearing a terminal hydroxyl group and a tert-butyl ester-protected carboxyl handle for modular PROTAC assembly. Its flexible PEG scaffold can improve solubility and provide spatial separation between binding motifs, while the tert-butyl ester enables controlled unveiling of the carboxylic acid for stepwise conjugation. The following sections describe the linker’s structural features and practical considerations for constructing targeted protein degraders.
Structure: The molecule consists of a repeating PEG ether chain terminated by a primary hydroxyl group and a tert-butyl ester-protected carboxyl functionality. It features multiple ether linkages, a tert-butyl ester-protected carboxyl group, and a flexible, hydrophilic polymer-like backbone that promotes aqueous compatibility.
Reactivity: PROTAC synthesis can use acid-mediated cleavage of the tert-butyl ester to generate the carboxylic acid, followed by activation and amide coupling to an amine-containing partner. Typical approaches employ acid for ester deprotection, then peptide-coupling reagents and appropriate bases for carboxyl activation and amide formation. The PEG ether backbone is generally stable under these conditions, supporting sequential, modular assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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