LG-PEG10-click-DBCO-Oleic
Cat No.: BP-501994
4.5 
LG-PEG10-click-DBCO-Oleic is a heterobifunctional PROTAC linker reagent combining a PEG-based spacer with a copper-free azide–alkyne cycloaddition (click) handle and a hydrophobic fatty-acid tail. Structurally, it provides a flexible, water-compatible chain length that can spatially separate a targeting ligand from an E3 ligase–recruiting moiety, while the DBCO group enables efficient conjugation to azide-functional partners under mild conditions. The oleic acid component offers membrane-associative or hydrophobic anchoring properties, which can be leveraged to enhance effective local concentration and to tune intracellular distribution of assembled targeted-degradation constructs. In PROTAC design, such linkers help optimize ternary complex formation by improving relative orientation and reducing steric hindrance between binding domains. Researchers value this reagent for modular assembly workflows, enabling rapid, robust synthesis of degraders and related conjugates for mechanistic studies of targeted protein degradation.
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker reagent, LG-PEG10-click-DBCO-Oleic, integrates a PEG-based spacer with a strained-alkyne DBCO handle and an oleyl-derived hydrophobic motif to support efficient, modular assembly of bifunctional degraders. Its design facilitates copper-free “click” conjugation to azide-bearing ligands, enabling controlled linker installation and flexible spatial presentation of binding elements. The subsequent points describe the structure and practical reactivity considerations for constructing PROTACs using this linker.
Structure: The molecule contains a poly(ethylene glycol) spacer that provides conformational flexibility, a DBCO strained-alkyne for bioorthogonal cycloaddition, and an oleyl-derived hydrophobic segment. It features ether linkages within the PEG chain and a cyclooctyne core suited for rapid azide capture, yielding stable triazole-linked conjugates.
Reactivity: Use this linker in copper-free azide–alkyne cycloaddition to couple DBCO with azide-functional protein-binding ligands or intermediate PROTAC components. Reactions are typically performed under mild conditions compatible with sensitive biomolecule conjugates, using polar organic solvents or buffered mixtures to maintain solubility. No copper catalyst is required, reducing oxidative side reactions; the mechanism proceeds via strain-promoted cycloaddition to form a triazole linkage.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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