m-PEG10-Boc
Cat No.: BP-501801
4.5 
m-PEG10-Boc is a mono-functional polyethylene glycol linker bearing a methoxy terminus and a Boc-protected group, providing a chemically versatile scaffold for PROTAC and targeted protein degradation workflows. Structurally, it consists of a PEG chain of intermediate length terminated with a Boc functionality, which can be removed under standard conditions to reveal a reactive handle for subsequent coupling to ligands or warheads. In PROTAC design, PEG linkers are widely used to tune linker length, conformational flexibility, and solubility, thereby improving the effective spatial relationship between the E3 ligase–binding moiety and the target-binding ligand while reducing nonspecific aggregation. The Boc group enables controlled, stepwise synthesis, helping researchers build conjugates with defined attachment points and minimize premature side reactions. Overall, m-PEG10-Boc is valuable for generating well-behaved PROTAC intermediates and for optimizing degradation constructs where solubility and linker ergonomics are critical for reliable biochemical evaluation.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
m-PEG10-Boc is a polyethylene glycol-based linker bearing a tert-butyl ester-protected carboxyl group for flexible, water-compatible conjugation in targeted protein degradation workflows. Its PEG segment supports solubility and linker mobility, while the tert-butyl ester provides a protected carboxyl handle for controlled downstream coupling. This product is commonly used in PROTAC synthesis to connect ligands through stable linkages and to tune physicochemical properties of degraders. Detailed structural and reactivity considerations are provided below.
Structure: The linker consists of an m-PEG chain terminated with a tert-butyl ester-protected carboxyl group, featuring ether linkages within the PEG backbone and an ester at the protected terminus. Its amphiphilic character supports aqueous compatibility, and the tert-butyl ester offers chemical stability under mild conditions until deprotection is initiated.
Reactivity: The tert-butyl ester can be preserved during earlier synthetic steps and then cleaved using standard acid-mediated methods to generate the corresponding carboxylic acid. Subsequent PROTAC-forming steps commonly rely on amide/urea coupling or other nucleophilic substitution strategies, using coupling reagents and appropriate bases in compatible solvents. Reaction design should account for PEG solubility and minimize conditions that promote PEG cleavage or side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
