m-PEG12-Boc
Cat No.: BP-501799
4.5 
m-PEG12-Boc is a methoxy-terminated polyethylene glycol linker bearing a Boc-protected functional group, providing a chemically defined, water-compatible spacer for PROTAC and targeted protein degradation construct assembly. Structurally, it consists of a PEG chain of intermediate length that confers conformational flexibility and improves solubility, while the Boc group serves as a protected handle for subsequent functionalization under appropriate deprotection conditions. In PROTAC design, such PEG-based linkers are commonly used to tune the spatial relationship between a target-binding ligand and an E3-recruiting moiety, helping to reduce steric clashes and maintain productive ternary complex formation. The PEG segment can also mitigate aggregation and promote homogeneous behavior in aqueous assays, which is important for evaluating degradation potency and kinetics. As a modular building block, m-PEG12-Boc supports systematic linker optimization, enabling researchers to rationally vary linker length and attachment chemistry to improve targeted degradation performance.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG12-Boc is a polyethylene glycol (PEG)-based linker bearing a tert-butyl ester-protected carboxyl handle, designed to support PROTAC assembly by providing solubility, conformational flexibility, and synthetic compatibility. Its PEG character helps mitigate aggregation and can improve handling of conjugates, while the tert-butyl ester enables controlled unveiling of the carboxylic acid during linker-to-ligand coupling. The detailed structural and reactivity considerations for PROTAC construction are provided below.
Structure: The linker comprises a PEG chain terminated with a tert-butyl ester-protected carboxyl group, featuring repeating ether linkages that confer hydrophilicity and segmental flexibility. The tert-butyl ester provides acid-labile carboxyl protection, enabling deprotection to reveal a carboxylic acid for subsequent coupling.
Reactivity: The tert-butyl ester is typically cleaved under mild acidic conditions to generate the corresponding carboxylic acid for PROTAC synthesis. The resulting carboxylic acid can be activated for amide formation with amine-containing partners, often in polar aprotic solvents with a suitable coupling reagent and base. Reaction design should preserve PEG integrity and avoid conditions that promote PEG cleavage or unwanted side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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