m-PEG37-NHS ester
Cat No.: BP-501878
4.5 
m-PEG37-NHS ester is a monofunctional methoxy-capped polyethylene glycol linker bearing an N-hydroxysuccinimide (NHS) ester for efficient amide-bond formation with primary amines. Structurally, it consists of a long, flexible PEG chain that provides hydrophilicity, steric spacing, and reduced nonspecific interactions, terminating in an NHS-activated carboxylate suitable for conjugation. In PROTAC and targeted protein degradation workflows, this linker is used to connect an amine-containing ligand (e.g., an E3 ligase binder or a targeting moiety) to a complementary component, while the PEG segment acts as a spacer that can improve effective reach and orientation for ternary-complex formation. Its practical value lies in enabling modular synthesis of degradation constructs with tunable linker length and minimized aggregation, facilitating systematic structure–activity studies and optimization of cellular degradation potency.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG37-NHS ester is a heterobifunctional PEG linker designed for efficient conjugation of biomolecule targeting ligands in PROTAC workflows. Its NHS-ester functionality enables formation of stable amide bonds under mild aqueous conditions, while the PEG spacer improves solubility and can help modulate effective linker length and flexibility in ternary-complex formation. The detailed structural and reaction considerations for constructing PROTACs with this linker are provided below.
Structure: The linker consists of a polyethylene glycol chain terminated with an N-hydroxysuccinimide ester (NHS ester). It contains an amide-forming activated carboxylate, ether-rich PEG segments, and a succinimide leaving group. The resulting material is typically water-compatible and exhibits flexible, hydrophilic spacer behavior.
Reactivity: The NHS ester reacts primarily with primary amines to form amide bonds via nucleophilic acyl substitution. Suitable conditions generally use buffered aqueous media at near-neutral pH, with NHS ester stability supported by avoiding strongly basic environments. Common catalysts are not required; however, fresh reagent preparation and controlled stoichiometry help drive coupling. After conjugation, unreacted NHS ester is commonly quenched or removed prior to subsequent PROTAC assembly steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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