m-PEG37-Propargyl
Cat No.: BP-502071
4.5 
m-PEG37-Propargyl is a methoxy-terminated PEG linker bearing a terminal propargyl (alkyne) functional group. Structurally, it consists of a flexible polyethylene glycol chain of extended length that provides water solubility and conformational freedom, while the propargyl moiety serves as a bioorthogonal handle for covalent attachment. In PROTAC and targeted protein degradation workflows, such PEG linkers are commonly used to tune the spatial relationship between the ligand-binding warhead and the E3 ligase recruiter, helping maintain productive ternary-complex formation by reducing steric constraints and promoting favorable linker dynamics. The terminal alkyne enables efficient conjugation strategies, for example via copper-catalyzed or strain-promoted azide–alkyne cycloaddition, to assemble multi-component degraders under mild conditions. This product is valuable for researchers optimizing linker length, flexibility, and conjugation chemistry to improve synthesis reliability and support systematic structure–activity studies in targeted degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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m-PEG37-Propargyl is a polyethylene glycol (PEG)-based bifunctional linker designed to support targeted protein degradation workflows in PROTAC construction. Its PEG scaffold provides conformational flexibility and improved solubility, while the propargyl handle enables efficient conjugation to ligands that bear complementary reactive groups. This combination facilitates modular assembly of PROTACs and can help tune linker length and hydrophilicity to optimize ternary complex formation and degradation performance. The detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a PEG ether backbone substituted with a terminal propargyl group. It features repeating C–O ether linkages that confer hydrophilicity and chain flexibility, alongside a carbon–carbon triple bond typical of terminal alkynes. Overall, it behaves as an ether-rich, polar macromolecular scaffold suitable for bioconjugation.
Reactivity: The terminal alkyne is suited for copper-catalyzed azide–alkyne cycloaddition with azide-bearing partners, forming a stable triazole linkage under commonly used conditions. Alternatively, it can participate in strain-promoted azide–alkyne cycloaddition when paired with cyclooctynes, avoiding copper. Typical PROTAC assembly uses polar organic solvents or aqueous mixtures compatible with PEG and preserves ligand integrity; catalyst choice and oxygen control can be important for reproducible coupling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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