m-PEG48-amine
Cat No.: BP-501776
4.5 
m-PEG48-amine is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal primary amine, providing a long, flexible hydrophilic chain well suited for bioconjugation chemistry. Structurally, it combines an ether-rich PEG backbone with a single functional handle for coupling, enabling attachment to PROTAC components or other targeting ligands through amide-forming reactions, reductive amination, or related linker strategies. In targeted protein degradation designs, PEG linkers are frequently used to tune the effective distance and conformational freedom between the ligand-binding moiety and the E3-ligase recruiting element, thereby improving ternary complex formation and reducing steric mismatch. The extended solvation shell can also enhance aqueous solubility and mitigate nonspecific aggregation, supporting reproducible synthesis and characterization. As a research tool, this linker facilitates systematic optimization of linker length and attachment geometry in PROTACs, helping researchers evaluate how linker architecture influences degradation potency and selectivity.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG48-amine is a polyethylene glycol (PEG)-based linker designed to provide a flexible, hydrophilic spacer for assembling PROTACs and related targeted protein degradation constructs. Its ether-rich backbone helps modulate solubility and presentation of functional groups, while the terminal amine enables robust conjugation to ligands or reactive intermediates. The subsequent points describe the structural features and practical reactivity considerations for PROTAC synthesis in detail.
Structure: The linker consists of a PEG chain bearing multiple ether linkages, terminating in a primary amine. Its flexible polyether backbone promotes conformational mobility, while the terminal nucleophilic nitrogen supports formation of stable amide or related linkages under standard bioconjugation chemistries.
Reactivity: The terminal amine can be used for nucleophilic acyl substitution or coupling to activated carboxylic acids (for example, via carbodiimide-mediated activation) to generate amide bonds, or for reductive amination with suitable aldehyde/ketone partners. Typical conditions employ aqueous or mixed aqueous/organic buffers at controlled pH, with coupling reagents such as carbodiimides and, when needed, additives that suppress side reactions like hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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