m-PEG8-DSPE
Cat No.: BP-501862
4.5 
m-PEG8-DSPE is an amphiphilic, PEGylated phospholipid linker designed for constructing PROTAC-related conjugates and for integrating hydrophilic and membrane-associated elements within targeted degradation platforms. Structurally, it combines a methoxy-capped, medium-length poly(ethylene glycol) chain with a DSPE (distearoyl phosphatidylethanolamine) lipid tail, providing a stable hydrophobic anchor alongside a flexible, water-soluble spacer. In PROTAC design workflows, this type of linker can mediate effective presentation and spatial separation of functional moieties, improving the accessibility of ligands for binding to target proteins while simultaneously enabling association with lipid-containing delivery systems or membrane-proximal environments. Its value for targeted protein degradation research lies in supporting formulation-compatible conjugation strategies, enhancing solubility and biophysical handling, and enabling controlled architecture for multicomponent assemblies used to study degradation efficiency and cellular uptake.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG8-DSPE is an amphiphilic, PEGylated lipid linker designed to support targeted protein degradation workflows by improving solubility, bioconjugation handling, and delivery-relevant formulation behavior of PROTAC assemblies. Its PEG segment provides a hydrated, sterically stabilizing environment, while the DSPE lipid component enables membrane-associated interactions that can be advantageous for constructing and testing degradation systems in complex biological matrices. The detailed structural and reactivity characteristics are provided below.
Structure: The linker combines a polyethylene glycol chain with a phospholipid (DSPE) motif, incorporating ether linkages within the PEG domain and phosphodiester functionality in the lipid headgroup. Its amphiphilic architecture supports hydrophilic–lipophilic balance, with noncovalent interactions contributing to self-association tendencies in aqueous media.
Reactivity: m-PEG8-DSPE is typically used as a functional lipid/PEG handle for PROTAC-related conjugation strategies that rely on established phospholipid or PEG end-group chemistries. Suitable coupling approaches often involve nucleophilic substitution or carbodiimide-mediated amide formation when complementary reactive groups are present on the partner ligands. Mild aqueous buffer systems with controlled pH are commonly used, and purification is generally performed to remove unreacted linker and byproducts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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