N-Benzyl-N-bis-PEG4
CAS No.: 1680183-01-0
Cat No.: BP-501153
4.5 
N-Benzyl-N-bis-PEG4 is a PEG-based PROTAC linker featuring a benzyl tertiary amine core substituted with two polyethylene glycol chains (bis-PEG4). The linker’s defining structural element is its flexible, hydrophilic PEG architecture, which increases aqueous solubility and provides conformational freedom between the two conjugation termini, while the benzyl-bearing nitrogen serves as the stable attachment point that maintains the linker integrity during synthesis and subsequent coupling. In PROTAC design, such bis-PEG linkers are commonly used to spatially separate a target-binding ligand from an E3 ligase recruiter, promoting productive ternary-complex formation by reducing steric clashes and allowing the two binding domains to adopt favorable orientations. This makes N-Benzyl-N-bis-PEG4 valuable for optimizing linker length and flexibility in targeted protein degradation workflows, particularly when screening series require systematic modulation of physicochemical properties and inter-domain distance to improve degradation potency and experimental robustness.
Structure of 1680183-01-0
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This PROTAC linker, N-Benzyl-N-bis-PEG4, is designed to provide a flexible, hydrophilic polyethylene glycol-based spacer that can improve solubility and modulate the effective distance and orientation between a ligand and an E3-recruiting or target-binding moiety. Its PEG-rich architecture supports robust conjugation strategies commonly used in targeted protein degradation workflows. The following sections describe the linker’s structural features and practical considerations for PROTAC assembly in detail below.
Structure: The linker contains a benzyl-substituted nitrogen center bearing two PEG4 chains, creating a highly solvated, flexible polyether environment. Ether linkages within the PEG segments and the central N-benzyl tertiary amine provide conformational mobility, while two terminal hydroxyl groups serve as practical sites for further derivatization.
Reactivity: For PROTAC construction, this linker is typically derivatized through its two terminal hydroxyl groups by esterification, ether formation, or conversion to activated leaving groups; the central tertiary amine is not suited to routine acylation. Reactions are generally performed under standard alcohol-derivatization conditions using appropriate activating reagents, with polar aprotic solvents favored to maintain PEG solubility and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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