PEG2-ethyl acetate
CAS No.: 154773-33-8
Cat No.: BP-501220
4.5 
PEG2-ethyl acetate is a short polyethylene glycol–derived linker reagent featuring a terminal hydroxyl group and an ethyl ester at the opposite end with a short PEG2 spacer that provides controlled hydrophilicity and conformational flexibility. In PROTAC and targeted protein degradation constructs, such PEG-based linkers are commonly used to tune the spatial relationship between a ligand for the target protein and a ligand for an E3 ubiquitin ligase, thereby improving productive ternary-complex formation and reducing steric mismatch. The ether-rich PEG segment can help mitigate nonspecific hydrophobic interactions and improve aqueous handling during synthesis and biological evaluation, while the ethyl ester is typically hydrolyzed to a carboxylic acid before activation and coupling; the hydroxyl group can be activated or derivatized separately. This product is valuable for researchers optimizing linker length and polarity to balance solubility, binding geometry, and degradation potency in iterative PROTAC design workflows.
Structure of 154773-33-8
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PEG2-ethyl acetate is a polyethylene glycol-based linker reagent designed to support PROTAC assembly by providing a flexible, hydrophilic spacer that can improve solubility and help tune the spatial relationship between the targeting ligand and the E3 ligase-recruiting moiety. Its ether-rich character and ester functionality make it suitable for linker chemistry workflows in targeted protein degradation. The following points describe the structure and the practical reactivity considerations in detail below.
Structure: PEG2-ethyl acetate contains an ether-linked polyethylene glycol segment that confers hydrophilicity and conformational flexibility, coupled to an acetate ester end group. The molecule features an ester linkage and multiple ether oxygen atoms, supporting hydrogen-bonding interactions and favorable wetting/solvation behavior in polar media.
Reactivity: The acetate ester end group can participate in ester-based coupling strategies commonly used in PROTAC linker construction. Typical approaches involve nucleophilic substitution or acyl transfer under mild base or catalytic conditions, often using polar aprotic solvents to promote solvation and reaction control. Reaction design should prioritize compatibility with functional groups on both ligands and minimize hydrolysis by controlling moisture and reaction time.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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