PEG4-sulfonic acid
CAS No.: 173459-90-0
Cat No.: BP-501305
4.5 
PEG4-sulfonic acid is a polyethylene glycol–based linker bearing a terminal sulfonic acid group and a terminal hydroxyl group, providing a short, water-soluble tether with a defined chain length. In PROTAC architectures, PEG linkers are commonly used to tune the spatial relationship between the target-binding ligand and the E3 ligase recruiter, improving productive ternary complex formation by reducing steric constraints and enhancing solubility in aqueous assay conditions. The sulfonic acid mainly provides strong acidity and water solubility, while the terminal alcohol is the site that can be activated or derivatized for linker attachment that preserve the geometry required for effective proximity-induced ubiquitination. As a modular component, PEG4-sulfonic acid is valuable for researchers optimizing linker length, hydrophilicity, and charge distribution to balance potency, cooperativity, and physicochemical properties during targeted protein degradation studies.
Structure of 173459-90-0
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PEG4-sulfonic acid is a polyethylene glycol–based linker bearing a sulfonic acid functionality, designed to support PROTAC assembly by improving solubility and enabling reliable conjugation strategies to targeting ligands. Its hydrophilic PEG segment can help maintain productive conformations and aqueous compatibility during synthesis and biological evaluation. The subsequent points describe the structural features and practical reactivity considerations for constructing PROTACs using this linker.
Structure: The linker comprises a short PEG chain terminating in a sulfonic acid group, providing a highly polar, hydrogen-bonding-rich scaffold. It contains ether linkages within the PEG segment and a strongly acidic sulfonate moiety, typically present as a solvated anion under neutral to basic conditions.
Reactivity: The sulfonic acid can be used as a functional handle for PROTAC synthesis through standard sulfonyl activation or coupling approaches, depending on the complementary group on the partner ligand. Suitable conditions generally involve controlled pH to manage sulfonate ionization, activation with appropriate coupling reagents, and aqueous/organic mixed solvents to balance solubility. Mechanistically, formation of an activated sulfonate intermediate enables nucleophilic substitution or related bond-forming steps to connect ligands while preserving PEG integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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