SPDP-PEG7-acid
Cat No.: BP-502044
4.5 
SPDP-PEG7-acid is a heterobifunctional PEG-based linker reagent designed for constructing PROTACs and related targeted protein degradation conjugates. Structurally, it combines a terminal carboxylic acid for facile coupling to amine- or hydrazide-bearing ligands, with a PEG7 spacer that provides aqueous solubility and conformational flexibility. The PEG chain acts as a length and shielding element, helping to reduce steric interference between the two binding modules of a PROTAC and improving the effective presentation of each moiety to its target and E3 ligase partner. In typical workflows, the activated disulfide functionality of SPDP-derived linkers enables thiol-mediated conjugation, allowing researchers to connect the linker to cysteine-containing sites or thiol-functionalized warheads while preserving the disulfide exchange chemistry required for stable yet tunable linkage behavior under experimental conditions. This product is valuable for systematic linker-length and attachment-site optimization in targeted degradation studies, supporting more reliable synthesis and comparative evaluation of PROTAC architectures.
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* For research and manufacturing use only. Not for human or clinical use.
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SPDP-PEG7-acid is a polyethylene glycol-based PROTAC linker designed to connect a thiol-reactive SPDP (pyridyl disulfide) handle with carboxyl-functional conjugation sites. Its flexible PEG segment supports productive spatial presentation of the binding partners, while the disulfide exchange reactivity enables formation of stable, protein-compatible conjugates commonly used in targeted protein degradation workflows. The points below describe the linker’s structure and practical reactivity considerations for PROTAC assembly.
Structure: This linker contains a PEG7 hydrophilic spacer that provides conformational flexibility and improves solubility. It incorporates a pyridyl disulfide electrophile and a terminal carboxylic acid, enabling orthogonal conjugation chemistries. Multiple ether linkages and a disulfide bond govern its stability and reactivity profile.
Reactivity: The pyridyl disulfide moiety undergoes thiol–disulfide exchange with primary thiols or cysteine-containing ligands under mildly basic, aqueous-compatible conditions to generate a new disulfide-linked conjugate. Carboxyl activation can be performed using standard coupling strategies (e.g., carbodiimide-based activation with coupling partners such as amines) to install complementary handles. Reactions are typically carried out in buffered, oxygen-aware solvents to preserve thiol integrity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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