THP-PEG7-alcohol
CAS No.: 873110-21-5
Cat No.: BP-500330
Purity: ≥95%
4.5 
THP-PEG7-alcohol is a polyethylene glycol (PEG)–based linker featuring a terminal alcohol that can be used as a reactive handle for PROTAC synthesis and other targeted bioconjugation workflows. Structurally, it comprises a short PEG chain that provides a flexible, hydrophilic spacer between two functional motifs, while the alcohol enables further derivatization (for example, conversion to activated esters or coupling partners) to connect a targeting ligand and an E3 ligase–binding moiety. In PROTAC architectures, PEG linkers are widely employed to tune the effective distance and relative orientation of the recruited proteins, improving formation and stability of the ternary complex and thereby supporting efficient ubiquitination and degradation. This product is valuable for researchers seeking to systematically vary linker length and polarity to optimize degradation potency, selectivity, and solubility in targeted protein degradation experiments.
Structure of 873110-21-5
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
THP-PEG7-alcohol is a polyethylene glycol–based linker designed to connect a ligandable warhead to an E3-recruiting element in PROTAC architectures. Its PEG-rich segment provides conformational flexibility and improved solubility, which can enhance productive ternary complex formation and support efficient targeted protein degradation workflows. The following sections describe the linker’s structural attributes and practical considerations for assembling PROTAC conjugates in the laboratory.
Structure: The linker comprises a tetrahydropyran-protected PEG chain terminating in a primary alcohol. It contains ether linkages characteristic of PEG, plus an acetal-type THP motif that can be selectively transformed under appropriate conditions. The resulting amphiphilic character supports aqueous compatibility and flexible linker behavior.
Reactivity: The terminal alcohol enables standard PROTAC conjugation strategies such as esterification or ether formation after converting to an activated derivative (for example, via common coupling reagents). The THP group can be maintained during coupling steps and later removed under mild acid-promoted conditions to reveal a reactive hydroxyl for subsequent functionalization. Typical procedures use polar organic solvents and bases compatible with PEG-containing substrates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
