NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2)

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NR4A2 (Nuclear Receptor Subfamily 4 Group A Member 2) is a protein encoded by the NR4A2 gene in humans. NR4A2 can interact with DNA in various ways. As monomers, NR4A2 and other members of the N4R4A subfamily interact with the so-called NBRE sequence (AAAGGTCA). NR4A2 also interacts with DNA to form a heterodimer with RXR and combines NBRE and DR5 response elements. NR4A2 can also be homodimerized and heterodimerized with other members of the NR4A family, and combine the so-called NuRE sequences with ER10 structure. Mutations in NR4A2 are associated with dopaminergic disorders, including Parkinson's disease, schizophrenia and manic depression.

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