1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl 4-methylbenzenesulfonate
CAS No.: 129086-10-8
Cat No.: BP-501532
Purity: ≥95%
4.5 
1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl 4-methylbenzenesulfonate is a PEG-like, ether-rich linker bearing a terminal phenyl group and a sulfonate leaving group for controlled functionalization. Structurally, it consists of a long, flexible polyether chain with multiple oxygen atoms that enhance solubility and conformational freedom, while the terminal sulfonate activates the end of the linker toward nucleophilic substitution. In PROTAC design, such activated linkers are used to connect a ligand or warhead-bearing nucleophile to the complementary partner, enabling the formation of a stable conjugate that can span the distance between the target-binding moiety and the E3 ligase ligand. The ether-rich backbone can reduce steric penalties and help maintain productive ternary-complex formation by allowing relative reorientation of the two binding domains. This reagent is valuable for constructing modular targeted degradation probes, facilitating systematic linker-length and polarity optimization in experimental workflows.
Structure of 129086-10-8
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This PROTAC linker, 1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl 4-methylbenzenesulfonate, is designed to serve as a chemically robust coupling handle for assembling heterobifunctional degraders. Its ether-rich scaffold provides conformational flexibility and favorable solubility characteristics, while the sulfonate leaving group enables efficient bond formation under standard synthetic conditions. The following sections describe the linker’s structure and the practical reactivity considerations relevant to PROTAC construction.
Structure: The molecule contains a long, pentaoxaether chain incorporating multiple ether oxygen atoms, connected to a phenyl-bearing terminus. It features an aryl sulfonate ester at the reactive end, with aromatic rings and ether linkages that together support flexibility and polarity.
Reactivity: The sulfonate ester is suited for nucleophilic substitution reactions used to connect PROTAC warheads and ligands. In typical linker-assembly workflows, base-mediated activation of a nucleophile (such as an alcohol, thiol, or amine) promotes displacement of the sulfonate group via an SN-type mechanism under anhydrous, inert or controlled conditions. Common solvents include polar aprotic media, and catalysts are selected based on nucleophile identity and compatibility with functional groups.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
