t-boc-N-amido-PEG8-alcohol
CAS No.: 1345337-22-5
Cat No.: BP-500538
Purity: >97%
4.5 
t-boc-N-amido-PEG8-alcohol is a heterobifunctional PEG linker with an N-protected amine and an alcohol. Structurally, it contains an N-Boc-protected primary amine connected through PEG8 to a terminal hydroxyl group. The alcohol can be activated, esterified, etherified, or converted into a leaving group, while acid-mediated N-Boc removal reveals a primary amine for amide, urea, carbamate, or sulfonamide formation. In PROTAC and related targeted protein degradation research, the differentiated alcohol and protected amine support sequential functionalization across a long hydrophilic spacer and should not be described as a Boc-protected amide. Its defined architecture allows researchers to evaluate how linker polarity, flexibility, attachment sequence, and terminal-group selection influence conjugate preparation and the spatial requirements of productive target–E3 ligase engagement. Clear assignment of the protected and reactive groups also supports reproducible reaction planning and systematic comparison of alternative linker designs in research-focused targeted protein degradation workflows.
Structure of 1345337-22-5
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t-Boc-N-amido-PEG8-alcohol is a polyethylene glycol–based linker building block designed for constructing PROTACs and related targeted protein degradation conjugates. Its PEG segment provides conformational flexibility and aqueous compatibility, while the terminal alcohol enables reliable functionalization toward linker-to-ligand attachment. The Boc-protected amide functionality supports controlled coupling strategies that help maintain synthetic fidelity during multistep assembly. Detailed structural and reactivity considerations are provided below.
Structure: This molecule contains a PEG chain terminated by a primary alcohol and an N-amido functionality protected as a Boc carbamate. The structure features ether linkages within the PEG backbone, a carbamate carbonyl, and an amide linkage, offering high polarity and hydrogen-bonding capacity. Overall, it is typically a hydrophilic, flexible linker suitable for bioconjugation.
Reactivity: The terminal alcohol can be converted into activated derivatives (for example, halides, mesylates, or other leaving-group forms) to enable substitution or coupling with nucleophilic partners used in PROTAC synthesis. The Boc-protected amide is commonly deprotected under acid conditions to reveal a reactive amine for subsequent amide- or urea-forming steps. These transformations generally proceed via standard nucleophilic substitution and acylation/carbamate deprotection principles, using inert atmospheres and appropriate anhydrous solvents as required by the chosen coupling chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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