Ald-C2-PEG4-azide
CAS No.: 2030118-14-8
Cat No.: BP-501421
Purity: 95%
4.5 
Ald-C2-PEG4-azide is an aldehyde-terminated, short polyethylene glycol (PEG) linker bearing a terminal azide functionality, designed for modular PROTAC assembly. The C2 aldehyde handle provides a chemically addressable group for conjugation or derivatization, while the PEG4 segment confers hydrophilicity and conformational flexibility that can reduce steric constraints between the ligand-recruiting moieties. The azide group enables efficient bioorthogonal coupling (commonly via copper-free azide–alkyne cycloaddition) to attach the linker to an alkyne-functional partner, allowing controlled placement of the two binding domains within a single degrader construct. In targeted protein degradation research, such linkers are used to tune linker length, polarity, and spatial orientation, thereby influencing ternary complex formation and the resulting ubiquitin–proteasome–dependent degradation efficiency. This product is valuable for rapid linker optimization and for generating chemically well-defined PROTACs for mechanistic and structure–function studies.
Structure of 2030118-14-8
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Ald-C2-PEG4-azide is a PEG-based bifunctional linker designed for modular PROTAC assembly, combining an aldehyde handle with an azide for orthogonal conjugation. Its flexible poly(ethylene glycol) segment supports productive ternary complex formation by improving linker solubility and conformational freedom. The aldehyde enables controlled formation of reversible or derivatizable intermediates, while the azide provides a reliable handle for click-type coupling. The following sections describe the linker’s structure and practical reactivity considerations in PROTAC workflows.
Structure: The linker contains an aldehyde-derived electrophilic group connected through a short alkyl spacer to a PEG chain terminating in an azide. It features ether-rich PEG segments, an azide functional group, and carbonyl-containing chemistry, yielding high polarity and improved aqueous compatibility typical of PEG linkers.
Reactivity: The aldehyde can be engaged under standard carbonyl chemistry to form Schiff base-type intermediates or to support derivatization, typically in buffered, mildly controlled conditions to limit side reactions. The terminal azide is well suited for copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne reactions, enabling chemoselective installation of targeting warheads. Common solvents include polar aprotic or aqueous mixtures compatible with click coupling, with catalyst choice tailored to protein stability.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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