Amino-PEG16-acid
Cat No.: BP-501952
4.5 
Amino-PEG16-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal primary amine and a terminal carboxylic acid, connected through a PEG chain of approximately sixteen ethylene glycol units. Structurally, the flexible, hydrophilic PEG backbone provides an extended spacer that can reduce steric interference between a ligand that recruits an E3 ligase and a ligand that binds the target protein. In PROTAC design, this linker enables conjugation via amide coupling or related chemistries to attach each binding moiety while maintaining sufficient spatial separation for productive ternary complex formation. The amine–acid functionality supports straightforward stepwise synthesis and purification of linker intermediates, facilitating systematic optimization of linker length and attachment geometry. As a result, Amino-PEG16-acid is a useful building block for targeted protein degradation research, where tuning linker properties can directly affect binding cooperativity, cellular uptake, and overall degradation efficiency.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Amino-PEG16-acid is a PEG-based bifunctional linker designed for modular assembly of PROTACs, enabling efficient spatial separation and improved solubility of conjugates. Its flexible ethylene glycol segments help accommodate diverse ligand geometries and can reduce steric mismatch during ternary complex formation. The terminal functional groups support chemoselective coupling strategies, making this linker well suited for constructing targeted protein degraders. The following sections describe the structure and reactivity considerations in detail below.
Structure: Amino-PEG16-acid contains a poly(ethylene glycol) chain with terminal amine and carboxylic acid functionalities. The linker features repeating ether linkages that confer high conformational flexibility, hydrophilicity, and reduced aggregation. It is typically handled as a polar, water-compatible scaffold with functional groups suitable for amide or amine-based conjugations.
Reactivity: The carboxylic acid can be activated for amide bond formation with amine-bearing partners using standard coupling chemistries (for example, carbodiimide-based systems with additives) under mildly controlled conditions. The terminal amine enables alternative coupling modes such as nucleophilic acyl substitution after acid activation. Solvents commonly used include polar aprotic media or aqueous/organic mixtures, chosen to preserve ligand stability and maintain linker solubility.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
