Amino-PEG23-acid
Cat No.: BP-501840
4.5 
Amino-PEG23-acid is a polyethylene glycol (PEG) linker bearing a terminal primary amine and a carboxylic acid, providing a flexible, hydrophilic chain of approximately 23 ethylene glycol repeat units. Its bifunctionality enables robust conjugation strategies in PROTAC construction: the amine can be used for amide coupling, reductive amination, or other nucleophile-driven attachment to a targeting ligand, while the terminal acid can be activated (e.g., as an ester or activated carboxylate) to connect to the complementary binding element. The long, conformationally mobile PEG segment acts as a spacer that reduces steric interference between the two recruited proteins, helps tune effective linker length, and can improve aqueous solubility of the assembled degrader. In targeted protein degradation research, such PEG-based linkers are widely used to systematically vary geometry and maintain productive ternary complex formation, supporting optimization of degradation potency and selectivity in iterative PROTAC workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG23-acid is a polyethylene glycol (PEG)-based bifunctional linker designed to support targeted protein degradation workflows in PROTAC constructs. Its flexible, hydrophilic spacer characteristics help tune the effective distance and orientation between a ligand and an E3-recruiting or target-binding module, often improving conjugate behavior in aqueous environments. The amine and carboxylic acid functionalities enable robust, widely used coupling strategies for assembling PROTACs. Detailed structural and synthetic considerations are provided below.
Structure: The linker comprises an oligo(ethylene glycol) chain terminated with a primary amine and a carboxylic acid. It features repeating ether linkages that confer conformational flexibility and strong water compatibility, alongside amide- or ester-forming functional groups suitable for covalent conjugation.
Reactivity: The carboxylic acid can be activated for amide-bond formation with amines using standard coupling chemistries (for example, carbodiimide-based systems with an appropriate additive) in polar aprotic or mixed aqueous/organic solvents. Alternatively, the amine can be used for coupling to activated carboxylates or for forming stable amide linkages. These transformations proceed via acyl-activation followed by nucleophilic substitution to install the linker into PROTAC scaffolds.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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