Amino-PEG23-amine
Cat No.: BP-501971
Purity: >95%
4.5 
Amino-PEG23-amine is a heterobifunctional polyethylene glycol (PEG) linker bearing terminal primary amine groups, providing a long, flexible hydrophilic spacer suitable for conjugation chemistry. Its extended chain length and ether-rich backbone confer conformational mobility and can reduce steric interference between a ligand moiety and an E3-recruiting or targeting element, while improving aqueous solubility of the assembled construct. In PROTAC design, this linker serves as a molecular “distance and orientation” element that connects two functional partners (for example, a target-binding ligand and an E3 ligase recruiter) through amide- or related coupling strategies, thereby enabling formation of the ternary complex required for ubiquitination and subsequent targeted protein degradation. As a modular PEG spacer, it is valuable for systematic optimization of linker length, flexibility, and linker–protein accessibility, often supporting improved degradation potency and selectivity across diverse target classes.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG23-amine is a polyethylene glycol-based bifunctional linker designed to connect a ligand for a target protein with an E3 ligase recruiter in PROTAC constructs. Its flexible, hydrophilic spacer helps maintain productive spatial orientation and can reduce steric constraints that often limit ternary complex formation. The linker’s two terminal amines enable straightforward conjugation chemistries, supporting modular PROTAC assembly. Detailed structural and reactivity considerations are provided below.
Structure: Amino-PEG23-amine consists of a repeating ethylene glycol chain terminated by primary amine groups. The linker contains multiple ether linkages along a flexible polyether backbone, providing high polarity and conformational mobility. The terminal amines offer nucleophilic functionality suitable for amide or urea formation and related coupling reactions.
Reactivity: The terminal primary amines can be used to form PROTAC linkages via amide coupling (using activated carboxylic acids such as NHS esters or acid chlorides) or via carbamate/urea-forming routes using appropriate electrophiles (e.g., isocyanates or activated carbonyl derivatives). Typical conditions employ anhydrous or buffered organic solvent systems with base to promote nucleophilic substitution. Coupling is generally performed under inert atmosphere when moisture-sensitive activators are used, and purification is commonly required to remove excess activating reagents and byproducts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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