Amino-PEG24-CH2-Boc
Cat No.: BP-502012
4.5 
Amino-PEG24-CH2-Boc is a polyethylene glycol (PEG) linker building block featuring a terminal primary amine and, at the opposite end, a tert-butyl ester-protected carboxyl group connected through a methylene-containing segment. Structurally, the long PEG segment provides a flexible, hydrophilic spacer that can reduce steric interference and improve solubility of conjugates, while the tert-butyl ester-protected carboxyl group enables controlled downstream coupling after deprotection and activation. In PROTAC and targeted protein degradation designs, PEG linkers are commonly used to tune the effective distance and relative orientation between the ligand warhead and the recruiting moiety, thereby facilitating formation of a productive ternary complex and supporting efficient ubiquitination-dependent degradation. This reagent is valuable for researchers seeking modular, experimentally tractable linker chemistry to optimize linker length, flexibility, and conjugation sites when assembling degraders for structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG24-CH2-Boc is a polyethylene glycol (PEG)-based bifunctional linker designed for constructing PROTACs and related targeted protein degradation conjugates. Its PEG segment provides conformational flexibility and improved solubility, while the terminal amino handle supports selective bioconjugation to ligands. The Boc-protected functionality offers controlled reactivity during multi-step synthesis. Detailed structural and reactivity considerations are provided below to guide experimental assembly of degradation molecules.
Structure: The linker contains a PEG chain terminated with a primary amino group and a methylene spacer, along with a Boc-protected carbonyl functionality. It features ether linkages within the PEG backbone, flexible sp3-rich segments, and a carbamate motif from Boc protection, supporting water-compatible physicochemical behavior.
Reactivity: PROTAC assembly commonly uses orthogonal protection strategies: Boc can be removed under standard acid-mediated conditions to reveal the amine, followed by coupling to activated carboxylates or electrophilic intermediates on targeting ligands. The amino group typically participates in amide bond formation via carbodiimide or activated ester chemistry, using polar aprotic solvents and bases. Reaction design should preserve PEG integrity and avoid harsh conditions that can degrade linker components.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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