Amino-PEG28-acid
Cat No.: BP-501768
4.5 
Amino-PEG28-acid is a PEG-based bifunctional linker featuring a terminal amino group and a terminal carboxylic acid, designed for modular conjugation in targeted protein degradation constructs. The long, flexible polyethylene glycol chain provides an extended hydrophilic spacer that can reduce steric interference between a ligand and an E3-recruiting moiety, while the amino and acid termini enable robust coupling chemistries such as amide formation or other standard functional group interconversions. In PROTAC design, this linker serves to position the two binding elements at an appropriate distance and orientation to promote formation of a productive ternary complex, thereby improving the probability of ubiquitination and subsequent proteasomal degradation of the target protein. Its extended length and water solubility make it particularly useful when optimizing linker length-dependent degradation profiles, solubility, and cellular compatibility across structure–activity studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG28-acid is a PEG-based PROTAC linker building block designed to connect ligands while providing a hydrophilic, flexible spacer that can improve solubility and enable productive ternary-complex formation. Its functional handles support modular synthesis of targeted protein degraders, facilitating systematic optimization of linker length, polarity, and attachment geometry. The detailed structural and synthetic considerations for PROTAC construction are provided below.
Structure: Amino-PEG28-acid comprises a terminal amino group and a terminal carboxylic acid on a polyethylene glycol chain, offering a flexible, ether-rich backbone. The molecule contains multiple ether linkages and a primary amine, enabling amide or ester formation and stable conjugation chemistry. Its PEG character confers strong water compatibility and reduced aggregation.
Reactivity: The carboxylic acid can be converted to activated intermediates (for example, acid chlorides or coupling-activated esters) under standard peptide-coupling or acylation conditions to form amide bonds with ligand amines. The terminal amino group can be used for coupling to activated carboxylates or for reductive amination workflows where appropriate. Common reagents include carbodiimide-based coupling systems with additives, using polar aprotic solvents and controlled pH to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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