Amino-PEG32-acid
Cat No.: BP-501796
4.5 
Amino-PEG32-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal amino group and a terminal carboxylic acid, with an extended PEG chain that provides high aqueous solubility and conformational flexibility. Structurally, the linker is characterized by a long, ether-rich backbone that can act as a spacer between a ligand and an E3-recruiting or target-binding moiety, reducing steric interference and helping maintain productive binding geometries. In PROTAC design, this type of linker is commonly used to connect two functional components through amide coupling (via the carboxyl group) or amine-reactive chemistry (via the amino group), enabling efficient formation of the conjugate while preserving the ability of each ligand to engage its respective protein. Its long, hydrophilic chain supports improved handling in aqueous assays and can enhance the likelihood of productive ternary complex formation. Overall, Amino-PEG32-acid is a valuable tool for systematic linker optimization in targeted protein degradation research, particularly when spacer length and flexibility are critical for activity.
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* For research and manufacturing use only. Not for human or clinical use.
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This amino-PEG32-acid linker is designed for building PROTACs that require a flexible, hydrophilic spacer between a targeting ligand and an E3 ligase-binding moiety. Its PEG-based architecture supports favorable solubility and conformational freedom, which can improve productive ternary complex formation and degradation efficiency. The linker’s functional groups enable straightforward conjugation strategies, and the sections below describe its structure and practical reactivity considerations in PROTAC assembly.
Structure: Amino-PEG32-acid is a polyethylene glycol chain terminated by an amine and a carboxylic acid. The linker contains repeating ether linkages that confer high polarity and flexibility, with amide/ester-forming functional groups enabling robust covalent attachment to PROTAC ligands under standard organic synthesis conditions.
Reactivity: The carboxylic acid can be activated for coupling to amines (e.g., via carbodiimide-mediated ester or amide formation) or converted to activated intermediates for controlled conjugation. The terminal amine can participate in amide-bond formation with activated carboxyl derivatives. Typical PROTAC linker assembly uses dry organic solvents with base and coupling reagents, proceeding through nucleophilic acyl substitution and minimizing side reactions by maintaining appropriate pH and anhydrous conditions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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