Amino-PEG36-Boc
Cat No.: BP-501754
4.5 
Amino-PEG36-Boc is a polyethylene glycol linker bearing a terminal primary amine and a tert-butyl ester-protected carboxyl group, providing a flexible, hydrophilic chain that can be used to connect PROTAC-relevant building blocks while minimizing steric and nonspecific interactions. The long PEG segment acts as a molecular spacer, improving effective reach and conformational freedom between the ligand moieties that bind the target protein and the E3 ubiquitin ligase, thereby supporting productive ternary complex formation. In PROTAC design, this linker can be employed to conjugate or derivatize one end for attachment to a warhead or ligase-binding ligand, while the tert-butyl ester enables controlled synthetic handling and subsequent deprotection to reveal a carboxylic acid for further coupling. Its PEG-based architecture is particularly valuable for tuning solubility and maintaining linker-mediated dynamics during iterative synthesis and structure–activity relationship studies in targeted protein degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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Amino-PEG36-Boc is a polyethylene glycol (PEG)-based linker designed to provide a flexible, hydrophilic spacer for assembling PROTACs. Its PEG segment provides improved solubility and conformational adaptability for modular linker construction. The tert-butyl ester-protected carboxyl group provides a protected acid handle during PROTAC synthesis. The structure and reactivity considerations are described in detail below.
Structure: Amino-PEG36-Boc consists of a PEG chain bearing a terminal amino group and a tert-butyl ester-protected carboxyl group at the opposite end. It features repeating ether linkages that confer high polarity, rotational flexibility, and favorable aqueous compatibility, while the tert-butyl ester provides acid-labile protection of the carboxylic acid.
Reactivity: The terminal amino group is already available for coupling; acid-mediated cleavage of the tert-butyl ester provides the carboxylic acid when that handle is needed. After ester deprotection, the carboxylic acid can be activated for amide coupling to an amine-containing partner using standard coupling reagents in polar aprotic solvents. For carboxyl-side coupling, the mechanism involves activation of the acid followed by nucleophilic attack by an amine partner, yielding a stable amide linkage.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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