Amino-PEG36-CONH-PEG36-acid
Cat No.: BP-501881
4.5 
Amino-PEG36-CONH-PEG36-acid is a heterobifunctional, PEG-based linker featuring an amine terminus and a terminal carboxylic acid, connected through two long poly(ethylene glycol) segments that are joined by a central amide (CONH) linkage. The extended PEG chain length and flexible ether backbone provide high aqueous solubility and conformational freedom, while the amine and carboxyl groups enable orthogonal coupling chemistries to PROTAC components (e.g., attachment to a ligand through amide-bond formation or other amine/carboxyl-reactive strategies). In targeted protein degradation constructs, such linkers help position the E3 ligase-binding moiety and the target-binding warhead at an appropriate spatial distance and orientation to promote productive ternary complex formation, often improving degradation efficiency and reducing nonspecific interactions. This linker is therefore valuable for systematic PROTAC optimization, including tuning linker length, hydrophilicity, and conjugation handles for modular synthesis and comparative studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This amino-PEG36-CONH-PEG36-acid linker is designed to provide a flexible, hydrophilic spacer for assembling PROTACs that require controlled separation between a ligand and an E3-recruiting module. Its polyethylene glycol–based architecture supports favorable solubility and reduced non-specific interactions, while the central amide and terminal carboxylic acid enable widely used conjugation strategies. The linker’s properties make it suitable for systematic PROTAC optimization; detailed structural and reaction considerations are provided below.
Structure: The linker comprises repeating ethylene glycol units flanking a central amide (CONH) motif, terminating in a carboxylic acid and an amino functionality. Ether linkages confer high polarity and conformational flexibility, while the amide provides directional hydrogen-bonding and stability under standard coupling conditions.
Reactivity: The terminal carboxylic acid can be activated for amide-bond formation with amine-bearing ligands using common peptide-coupling chemistries under mild conditions. The amino group supports orthogonal coupling or further functionalization, enabling stepwise PROTAC synthesis. Typical approaches employ coupling reagents in compatible polar solvents, with base to promote nucleophilic acyl substitution, yielding stable amide linkages that preserve linker flexibility.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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