Amino-PEG7-amine
CAS No.: 332941-25-0
Cat No.: BP-501402
Purity: >97%
4.5 
Amino-PEG7-amine is a bifunctional polyethylene glycol (PEG) linker featuring terminal primary amines separated by a PEG chain of approximately seven ethylene glycol units. Structurally, it provides a flexible, hydrophilic spacer that can be used to connect two reactive partners through amide- or urea-forming coupling chemistries, or via reductive amination when appropriate carbonyl groups are present. In PROTAC and targeted protein degradation designs, this type of linker is valued for tuning the effective distance and relative orientation between the ligand that recruits an E3 ligase and the ligand that engages the target protein, thereby influencing formation and stability of the ternary complex. The PEG-based scaffold also helps reduce nonspecific hydrophobic interactions and improves aqueous solubility, which can facilitate synthesis, purification, and biological testing. Overall, Amino-PEG7-amine is a practical, widely used building block for constructing modular PROTAC architectures and for systematic linker optimization studies.
Structure of 332941-25-0
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Amino-PEG7-amine is a polyethylene glycol (PEG) based bifunctional linker designed for constructing PROTACs by connecting a target-binding ligand to an E3 ligase ligand through flexible, hydrophilic spacing. Its ether-rich backbone and terminal amines support robust conjugation strategies that help tune linker length, solubility, and conformational freedom. The detailed structure and reactivity considerations are provided below for researchers planning targeted protein degradation experiments.
Structure: Amino-PEG7-amine contains a PEG chain composed of repeating ether units, providing a flexible, water-compatible scaffold. Two primary amine termini enable formation of stable amide or urea linkages. The molecule features ether oxygen atoms that promote hydrogen bonding and improve overall polarity.
Reactivity: The terminal amines are suitable for standard bioconjugation reactions used in PROTAC synthesis, including coupling with activated carboxylic acids (forming amides) or reaction with isocyanates/carbonyl equivalents (forming ureas). Typical conditions employ amine-compatible coupling reagents, inert atmosphere when needed, and polar aprotic solvents to maintain solubility. Reaction progress is commonly monitored by analytical methods, and purification is performed to remove excess reagents and byproducts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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