Azido-PEG11-acid
Cat No.: BP-501744
4.5 
Azido-PEG11-acid is a heterobifunctional polyethylene glycol linker bearing a terminal azide group and a carboxylic acid, providing a flexible, hydrophilic spacer of extended length for PROTAC construction. Structurally, the PEG chain acts as a conformational buffer that reduces steric interference between the ligand-binding moieties, while the terminal azide enables efficient bioorthogonal conjugation via azide–alkyne cycloaddition (CuAAC or strain-promoted variants) or related click chemistry approaches. The carboxylic acid supports subsequent coupling to amine- or activated ester–containing partners (e.g., through amide bond formation), allowing researchers to position the reactive handle for controlled assembly of degraders. In targeted protein degradation research, this linker is valuable for tuning spatial arrangement and effective ternary complex formation, improving the likelihood of productive ubiquitination by the E3 ligase recruited by the PROTAC’s other components. Its water solubility and modular reactivity make it suitable for systematic linker optimization in biochemical and cell-based degradation studies.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Azido-PEG11-acid is a polyethylene glycol-based linker bearing a terminal azide and a carboxylic acid handle, making it well suited for modular PROTAC assembly. Its PEG segment promotes aqueous solubility and provides conformational flexibility between the target-binding ligand and the E3-ligase recruiting element. The azide functionality enables bioorthogonal conjugation strategies, while the acid group supports controlled coupling chemistry. The following sections describe its structure and practical reactivity considerations in PROTAC linker construction.
Structure: Azido-PEG11-acid is an amphiphilic PEG chain terminated by an azide group and a carboxylic acid. The molecule contains ether linkages along the PEG backbone, with a terminal organic azide and a carboxylate functionality. These features support hydrophilicity, flexibility, and stable covalent attachment points for PROTAC synthesis.
Reactivity: The terminal azide is compatible with copper-catalyzed or strain-promoted azide–alkyne cycloaddition approaches, enabling selective formation of triazole-linked conjugates under mild, orthogonal conditions. The carboxylic acid can be converted to activated derivatives (for example, acyl halides or carbodiimide-activated esters/amides) to couple to amine- or hydroxyl-containing ligands. Common solvents include polar aprotic media, and coupling is typically driven by base and dehydrating reagents, depending on the activation method.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
