Azido-PEG11-azide
CAS No.: 1392284-57-9
Cat No.: BP-501655
Purity: >95%
4.5 
Azido-PEG11-azide is a homobifunctional polyethylene glycol (PEG) linker featuring two terminal azide groups separated by an extended PEG chain. The long, flexible ethylene glycol backbone provides aqueous solubility and conformational spacing, while the azides serve as highly versatile handle groups for bioorthogonal conjugation, most commonly via copper-catalyzed or strain-promoted azide–alkyne cycloaddition, enabling efficient attachment to complementary alkyne-bearing ligands or probes. In PROTAC and targeted protein degradation workflows, this type of linker is used to bridge two functional modules—typically a target-binding moiety and an E3 ligase recruiter—allowing tuning of effective distance, relative orientation, and linker flexibility to optimize ternary complex formation. Its dual-reactive termini facilitate stepwise assembly and modular synthesis, supporting systematic structure–activity studies and improving reproducibility when comparing linker length and chemistry across degradation constructs.
Structure of 1392284-57-9
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Azido-PEG11-azide is a bifunctional polyethylene glycol linker designed for modular synthesis of PROTACs and other targeted protein degradation constructs. Its two terminal azide groups enable efficient, orthogonal conjugation to complementary reactive partners, supporting flexible linker installation and optimization of degrader geometry. The PEG-based scaffold provides aqueous compatibility and conformational spacing that can improve productive ternary complex formation. The following sections describe its structural features and practical reactivity considerations in PROTAC assembly.
Structure: Azido-PEG11-azide contains a flexible PEG chain terminated by azide functional groups. The linker features ether linkages within the polyether backbone and terminal azides suitable for click-type transformations. Its high polarity and water dispersibility arise from the PEG segment, while the azides provide defined, bioorthogonal handles.
Reactivity: The terminal azides are commonly engaged via copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, depending on the alkyne partner. Typical strategies use Cu(I) sources with stabilizing ligands and polar organic/aqueous solvent mixtures for the CuAAC route, while SPAAC uses ligand-free conditions to avoid copper. Mechanistically, cycloaddition forms a stable triazole linkage, enabling stepwise PROTAC construction under standard bioconjugation conditions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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