Azido-PEG24-alcohol
Cat No.: BP-501819
Purity: >95%
4.5 
Azido-PEG24-alcohol is a linear, polyethylene glycol (PEG) linker bearing a terminal azide group and a primary alcohol at the opposite end, providing a long, flexible hydrophilic spacer suitable for bioconjugation workflows. The azide functionality enables efficient copper-catalyzed or strain-promoted azide–alkyne cycloaddition chemistry, allowing researchers to couple this linker to complementary handles such as alkynes or cyclooctynes while maintaining chemical stability under typical PROTAC synthesis conditions. In targeted protein degradation (TPD) constructs, the extended PEG chain helps tune the spatial separation and conformational freedom between the ligand that recruits an E3 ligase and the ligand that binds the target protein, which can strongly influence ternary complex formation and degradation potency. This linker is particularly valuable for modular PROTAC assembly, late-stage functionalization, and improving solubility of conjugates, thereby facilitating systematic structure–activity studies and optimization of degradation performance.
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG24-alcohol is a polyethylene glycol (PEG)-based linker bearing a terminal azide functionality and a hydroxyl group, enabling modular attachment of targeting ligands in PROTAC construction. Its flexible, hydrophilic PEG scaffold can improve solubility and provide conformational spacing between binding elements, while the azide handle supports bioorthogonal conjugation strategies. The hydroxyl group further supports downstream synthetic modification. The following sections describe the structure and reactivity of this linker in detail.
Structure: The linker comprises a PEG chain terminated by an azide and an alcohol, featuring repeating ether (C–O–C) units that confer flexibility and hydrophilicity. The azide is a functional group suitable for chemoselective click-type reactions, while the terminal hydroxyl provides a reactive site for derivatization.
Reactivity: The azide group is typically used in copper-catalyzed azide–alkyne cycloaddition or related azide coupling workflows to connect PROTAC arms under mild, chemoselective conditions. Reaction design commonly considers ligand compatibility, aqueous/organic solvent mixtures, and oxygen sensitivity of catalysts. The PEG environment can enhance effective mixing and reduce nonspecific aggregation, supporting efficient formation of the linker–ligand conjugate.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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