Azido-PEG24-Boc
Cat No.: BP-502102
4.5 
Azido-PEG24-Boc is a PEG-based linker bearing a terminal azide functionality and a tert-butyl ester-protected carboxyl group, providing a chemically versatile spacer for PROTAC and targeted protein degradation workflows. Structurally, it consists of a long, flexible ethylene glycol chain that can reduce steric interference and improve effective reach between a ligand-bound targeting moiety and an E3 ligase recruiter. The terminal azide enables bioorthogonal conjugation strategies, most commonly via copper-free azide–alkyne cycloaddition (click chemistry), allowing researchers to connect the linker to alkyne-functional partners under conditions compatible with sensitive biomolecular reagents. The tert-butyl ester protects a carboxyl group for controlled deprotection and subsequent coupling when constructing multi-component degradation constructs. In PROTAC design, such linkers help tune spatial orientation, local concentration at the ternary complex interface, and overall physicochemical properties, supporting systematic optimization of degradation potency and selectivity in experimental studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Azido-PEG24-Boc is a polyethylene glycol (PEG) linker bearing an azide handle and a Boc-protected functional group, designed for modular assembly of PROTACs. Its flexible PEG scaffold supports productive ternary complex formation by improving linker solubility and conformational adaptability, while the azide enables bioorthogonal conjugation to complementary partners. The Boc functionality provides a protected reactive site for controlled deprotection and subsequent coupling. Detailed structural and reaction considerations are provided below.
Structure: The molecule comprises a PEG chain that provides a hydrophilic, conformationally flexible backbone, terminating in an azide group and a Boc-protected functionality. It contains ether linkages characteristic of PEG, along with an azide moiety and carbamate chemistry associated with Boc protection.
Reactivity: The azide is suitable for copper-catalyzed azide–alkyne cycloaddition or related azide click strategies, typically using standard ligands and inert, oxygen-controlled conditions to minimize side reactions. The Boc group can be removed under acidic conditions to reveal a reactive amine or related functionality, enabling coupling to electrophiles used in PROTAC synthesis. Solvent choice and purification should follow established linker–payload conjugation workflows to preserve linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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