Azido-PEG4-Amido-Tris
CAS No.: 1398044-55-7
Cat No.: BP-500329
Purity: 98%
4.5 
Azido-PEG4-Amido-Tris is a polyethylene glycol–based PROTAC linker featuring an azide functional group for bioorthogonal conjugation, a PEG4 chain length that provides aqueous solubility and spatial flexibility, and an amide-linked trisubstituted scaffold that serves as a robust attachment point for assembling bifunctional degraders. The azide enables efficient coupling to complementary alkyne-bearing ligands or handles via copper-free click chemistry, allowing researchers to connect target-binding warheads and E3 ligase recruiters with controlled linker length and geometry. The PEG segment helps mitigate steric hindrance and can improve effective intramolecular positioning, which is critical for productive ternary complex formation and subsequent ubiquitination-driven degradation. In targeted protein degradation research, this linker is valuable for modular PROTAC synthesis, enabling rapid optimization of conjugation sites and linker architecture while maintaining chemical stability under typical synthetic and analytical conditions.
Structure of 1398044-55-7
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Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker component designed to support efficient conjugation between ligands through a bioorthogonal azide handle and a stable amide-bearing scaffold. Its flexible polyethylene glycol segment helps modulate linker conformational freedom, often improving productive ternary complex formation and overall degradation performance in targeted protein degradation workflows. The detailed Structure and Reactivity parameters are provided below for researchers planning PROTAC synthesis and optimization.
Structure: The linker contains an azide functional group for click-type conjugation, a PEG-derived flexible spacer, and an amide linkage that provides chemical stability and defined connectivity. The scaffold supports polar, hydrogen-bonding interactions, while the ether-rich PEG segment increases solvation and conformational adaptability.
Reactivity: The azide enables copper-catalyzed azide–alkyne cycloaddition or related azide click strategies with suitably functionalized alkynes. PROTAC assembly typically proceeds under conditions compatible with sensitive ligands, using standard click reagents, appropriate base/additives, and solvent systems that maintain solubility. Reaction efficiency depends on ligand sterics, solvent polarity, and catalyst/ligand compatibility, following established click conjugation principles.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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