Benzyl-PEG13-alcohol
Cat No.: BP-501850
Purity: >95%
4.5 
Benzyl-PEG13-alcohol is a mono-functional polyethylene glycol (PEG) linker bearing a benzyl group at one terminus and a terminal primary alcohol at the other. Structurally, it consists of an ether-rich PEG chain of intermediate length that provides conformational flexibility and hydrophilicity, while the benzyl moiety offers a hydrophobic handle and the alcohol enables straightforward chemical functionalization. In PROTAC and targeted protein degradation designs, such PEG linkers are commonly used to tune the spatial relationship between the ligand-binding modules and to reduce steric clashes at the ternary-complex interface, thereby improving the productive geometry for E3 ligase recruitment and target engagement. The terminal alcohol can be converted into activated derivatives (e.g., ester or ether forms) to facilitate conjugation to warheads or E3-binding ligands under standard coupling chemistries. This product is valuable for researchers seeking to systematically optimize linker length and polarity to enhance solubility, stability, and degradation efficiency in experimental PROTAC workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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Benzyl-PEG13-alcohol is a PEG-based linker alcohol designed to support flexible, hydrophilic spacing between a target-binding ligand and an E3 ligase-recruiting moiety in PROTAC constructs. Its ether-rich poly(ethylene glycol) character helps tune linker length, solubility, and conformational freedom, which can improve productive ternary complex formation. The detailed Structure and Reactivity parameters for constructing PROTACs with this linker are provided below.
Structure: The molecule features a benzyl ether terminus linked to a long poly(ethylene glycol) chain bearing a terminal primary alcohol. Its backbone is dominated by repeating ether linkages, with an aromatic benzyl group providing a stable hydrophobic handle for conjugation. The overall structure is flexible and strongly hydrophilic.
Reactivity: As a terminal alcohol, it is well suited for standard PROTAC linker functionalization routes such as esterification or ether formation to connect to carboxylate- or halide-activated partner groups. Typical coupling strategies use activating reagents for carboxylic acids, or base-mediated substitution for electrophiles, often in polar aprotic solvents. Reaction conditions are generally chosen to preserve amide/ester stability and avoid PEG-chain cleavage, with mild bases and controlled temperatures commonly used in linker chemistry workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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