Benzyl-PEG4-acid
CAS No.: 127457-64-1
Cat No.: BP-501324
Purity: ≥95%
4.5 
Benzyl-PEG4-acid is a bifunctional polyethylene glycol (PEG) linker featuring a benzyl terminus and a carboxylic acid at the opposite end, connected through a four-unit PEG chain that provides a flexible, hydrophilic spacer. In PROTAC and targeted protein degradation constructs, this type of PEG linker is used to tune spatial separation and conformational freedom between the ligand that recruits an E3 ligase and the ligand that binds the target protein, thereby improving the probability of productive ternary complex formation. The benzyl ether serves as a protected/blocked hydroxyl terminus and can be cleaved by hydrogenolysis to reveal an alcohol, while the terminal carboxylic acid enables straightforward coupling to amines or other reactive groups via standard amide-forming or ester-forming strategies. Its PEG-based architecture often enhances aqueous solubility and can reduce nonspecific aggregation, supporting more reproducible degradation assay performance during linker optimization studies.
Structure of 127457-64-1
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Benzyl-PEG4-acid is a polyethylene glycol (PEG)-based PROTAC linker building block designed to provide a flexible, hydrophilic spacer between a ligand and an E3-recruiting or target-binding module. Its ether-rich chain supports favorable solubility and conformational adaptability, while the terminal carboxylic acid enables robust conjugation strategies commonly used in targeted protein degradation workflows. The following sections describe its structure and practical reactivity considerations for PROTAC assembly in detail below.
Structure: The linker contains a benzyl group connected to a PEG oligomer featuring repeating ether units, terminating in a carboxylic acid. It comprises aromatic and aliphatic segments linked through ether and carbon–carbon/heteroatom connections, with hydrogen-bonding functionality from the acid and ether oxygens that promote water compatibility.
Reactivity: The terminal carboxylic acid is suited for standard amide-forming coupling to PROTAC ligands bearing amines, or for ester/amide activation using carboxyl-activation reagents. Typical approaches rely on activating the acid under mild base conditions in polar aprotic solvents, followed by nucleophilic capture to form stable amide bonds. For PROTAC synthesis, the linker’s PEG ether segment generally remains inert, preserving linker integrity during coupling steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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