Benzyl-PEG6-THP
CAS No.: 230620-73-2
Cat No.: BP-501185
Purity: >95%
4.5 
Benzyl-PEG6-THP is a polyethylene glycol (PEG)–based PROTAC linker featuring a benzyl terminus and a six–ethylene glycol unit chain that is conjugated to a tetrahydropyran (THP) moiety, providing a flexible, hydrophilic spacer with a protected alcohol handle. In PROTAC architectures, PEG linkers are widely used to tune the effective distance and relative orientation between the target-binding ligand and the E3 ligase recruiting ligand, improving productive ternary-complex formation and reducing steric clashes. The THP-containing end group offers a chemically addressable site for further functionalization or controlled deprotection, enabling attachment to warheads or affinity handles while maintaining solubility and minimizing nonspecific hydrophobic interactions. This linker is valuable for researchers optimizing targeted protein degradation constructs, as its combination of conformational flexibility and aqueous compatibility can support systematic structure–activity relationship studies and enhance the manufacturability of conjugation intermediates.
Structure of 230620-73-2
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Benzyl-PEG6-THP is a PEG-based linker designed to support PROTAC assembly by providing a hydrophilic, conformationally flexible spacer between a target-binding ligand and an E3 ligase-recruiting moiety. Its ether-rich chain can enhance solubility and reduce steric mismatch, while the benzyl and THP functionalities enable practical synthetic handles for orthogonal coupling strategies. Detailed structural and reactivity considerations are provided below to guide researchers in linker incorporation into targeted protein degradation constructs.
Structure: The linker comprises a poly(ethylene glycol) chain with multiple ether linkages, imparting flexibility and strong hydrogen-bonding capacity. A benzyl group provides an aromatic handle, while THP denotes a protected hydroxyl functionality that can be selectively unmasked under appropriate conditions. Overall, it is an ether-rich, amphiphilic scaffold.
Reactivity: THP-protected alcohol functionality is typically compatible with protection/deprotection workflows used in PROTAC linker synthesis, enabling orthogonal functional-group manipulation. Coupling steps commonly rely on converting terminal groups into reactive electrophiles or nucleophiles, followed by nucleophilic substitution or ester/amide-forming reactions under standard organic synthesis conditions. Suitable solvents are those that dissolve PEG-containing intermediates and support clean activation, while catalysts are chosen to match the specific coupling chemistry and preserve the PEG ether backbone.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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