Benzyl-PEG7-acid
Cat No.: BP-501757
Purity: ≥95%
4.5 
Benzyl-PEG7-acid is a polyethylene glycol (PEG)–based linker featuring a benzyl end group and a terminal carboxylic acid, providing a flexible, hydrophilic spacer approximately seven ethylene glycol units long. The PEG chain and acid functionality make it suitable for modular PROTAC synthesis, where the linker must transmit spatial separation between a ligand that recruits an E3 ligase and a ligand that binds the target protein while maintaining productive ternary complex formation. In practice, the carboxyl group enables chemoselective coupling to complementary amine or activated ester partners, allowing attachment to either PROTAC “warhead” or “recruiter” fragments. The benzyl terminus offers a stable hydrophobic handle that can influence conformational preferences and solubility balance. This linker is valuable for targeted protein degradation research because PEG-based spacers often improve aqueous handling and can tune linker length and flexibility to optimize degradation potency and selectivity in iterative structure–activity studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Benzyl-PEG7-acid is a PEG-based PROTAC linker building block designed to connect a ligand-bearing warhead to an E3-recruiting moiety while providing conformational flexibility and improved aqueous compatibility. Its functional handles support modular PROTAC assembly, enabling systematic optimization of linker length and polarity for efficient ternary complex formation and targeted protein degradation. The following sections describe its structural features and practical reactivity considerations in PROTAC synthesis.
Structure: The linker comprises a benzyl-terminated polyethylene glycol chain incorporating an acid functionality. It contains multiple ether linkages within the PEG segment, providing flexibility and hydrophilicity, while the aromatic benzyl group contributes a stable hydrophobic anchor. The terminal carboxylic acid enables derivatization for amide or ester-forming coupling chemistry.
Reactivity: The carboxylic acid is suitable for activation and subsequent coupling to nucleophilic partners commonly used in PROTAC construction, such as amines or alcohols, to form amide or ester linkages. Typical approaches rely on carboxylate activation using standard peptide-coupling reagents under mild base conditions, often in polar aprotic solvents, followed by nucleophilic substitution. The PEG ether backbone is generally stable under these coupling conditions, supporting reliable linker transfer into larger PROTAC architectures.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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