Benzyl-PEG7-t-butyl ester
Cat No.: BP-501876
Purity: ≥95%
4.5 
Benzyl-PEG7-t-butyl ester is a PEG-based PROTAC linker featuring a benzyl terminus and a terminal tert-butyl ester, providing a flexible, hydrophilic chain length that can span the spatial gap between a target-binding ligand and an E3 ligase recruiter. The ether-rich PEG segment enhances aqueous solubility and conformational adaptability, which is critical for achieving productive ternary complex formation in targeted protein degradation workflows. The benzyl group serves as a stable aromatic handle for synthetic attachment to one PROTAC module, while the tert-butyl ester is a protected carboxyl functionality that can be selectively deprotected or converted to enable coupling to the complementary module under standard organic synthesis conditions. In PROTAC design, such linkers help tune linker length and polarity to improve degradation potency and selectivity by optimizing the relative orientation and effective proximity of the two binding domains. This product is therefore valuable for constructing and screening linker variants in structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Benzyl-PEG7-t-butyl ester is a PEG-based PROTAC linker designed to provide a flexible, hydrophilic spacer between a ligand and an E3 ligase-recruiting module. Its ether-rich backbone supports conformational freedom and improved solubility, while the ester functionality enables modular attachment strategies commonly used in targeted protein degradation workflows. The points below describe the linker’s structural features and practical considerations for PROTAC construction in experimental settings.
Structure: The linker contains a poly(ethylene glycol) segment that imparts hydrophilicity and conformational flexibility, connected to a benzyl group and a tert-butyl ester. It features ether linkages within the PEG chain and an ester linkage at the terminus, supporting stable handling under mild conditions.
Reactivity: The benzyl and tert-butyl ester functionalities are typically leveraged in stepwise conjugation schemes: benzyl groups are commonly removed by hydrogenolysis, while tert-butyl esters are cleaved under acid to reveal a carboxyl handle for amide or ester coupling. Standard PROTAC assembly often relies on carbodiimide-mediated coupling using activated carboxylic acids, with compatible bases and dry polar solvents to maintain PEG integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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