Biotin-PEG11-oxyamine HCl
Cat No.: BP-502176
Purity: >90%
4.5 
Biotin-PEG11-oxyamine hydrochloride is a PEG-based linker reagent featuring a biotin recognition handle and an 11-unit ethylene glycol spacer terminating in an oxyamine functionality. The long, flexible PEG chain provides aqueous solubility and spatial separation, reducing steric interference when the biotin moiety is used for affinity capture or localization. The oxyamine group enables chemoselective conjugation to carbonyl-containing partners (for example, aldehydes or activated carbonyls) via oxime or related bond-forming chemistries commonly used in linker design. In PROTAC and targeted degradation workflows, this construct can be used to append a biotin tag to a ligand or to a degradation scaffold, facilitating pull-down assays, enrichment of ternary complexes, and downstream analytical readouts such as immunoblotting or mass spectrometry after streptavidin capture. Its modular architecture and robust biotin–streptavidin interaction make it valuable for optimizing conjugate synthesis and validating degradation mechanisms.
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* For research and manufacturing use only. Not for human or clinical use.
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Biotin-PEG11-oxyamine HCl is a polyethylene glycol (PEG)-based linker designed to connect biotin-derived recognition elements to PROTAC scaffolds through an oxyamine functionality. Its flexible, hydrophilic PEG chain supports productive ternary complex formation by improving solubility and spatial presentation of the binding motifs. The oxyamine handle enables chemoselective conjugation strategies commonly used in targeted protein degradation workflows. The detailed structural and reactivity features are described below.
Structure: The linker comprises a biotin moiety tethered to a long PEG chain, terminating in an oxyamine hydrochloride salt. It contains ether linkages within the PEG segment and an amine functionality stabilized as an HCl salt, providing high polarity and water compatibility.
Reactivity: The oxyamine group is suited for nucleophilic, amine-directed coupling to activated carboxyl or carbonyl intermediates used in PROTAC synthesis. Typical approaches employ carbodiimide-mediated activation or related acyl-transfer chemistries under mild, anhydrous conditions, with bases to maintain nucleophilicity. Polar aprotic solvents are commonly used to preserve solubility, while reaction temperature and pH are adjusted to balance coupling efficiency and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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