Bis-MAL-PEG4-PEG12-Lysine-Tris(mPEG24)3
Cat No.: BP-502159
4.5 
Bis-MAL-PEG4-PEG12-Lysine-Tris(mPEG24)3 is a multifunctional, lysine-based, heterobifunctional PEG linker designed for targeted protein degradation constructs. Structurally, it combines two maleimide (MAL) termini with a branched PEG architecture that includes a short PEG spacer and a longer PEG segment, anchored to a lysine core and capped with three mPEG24 chains, yielding a highly hydrophilic, sterically flexible conjugation scaffold. In PROTAC design, the maleimide groups enable thiol–maleimide coupling to cysteine-containing ligands or engineered protein-binding modules, allowing controlled attachment of two degradation-relevant components while the PEG spacers tune effective molarity, solubility, and spatial orientation for ternary complex formation. The tris(mPEG24) capping improves aqueous compatibility and reduces nonspecific interactions, which can be advantageous for maintaining linker stability and minimizing aggregation during synthesis and biological testing. This product is therefore valuable for researchers engineering degraders that require robust, tunable linker geometry and improved handling properties.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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- Custom Synthesis & Design Service
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This PROTAC linker is a multifunctional, PEG-based lysine scaffold designed to connect two binding elements while providing high conformational flexibility and aqueous compatibility. Its extended polyethylene glycol architecture can reduce non-specific interactions and support efficient formation of productive ternary complexes in targeted protein degradation workflows. The sections below describe its structural features and practical considerations for linker installation and PROTAC assembly in research settings.
Structure: The linker comprises a lysine core bearing multiple PEG chains, including bis-MAL-terminated PEG segments and additional long mPEG units. It contains stable amide linkages from the lysine scaffold and ether linkages within PEG segments, yielding a highly hydrophilic, flexible, water-soluble polymeric architecture.
Reactivity: MAL (maleimide) functional groups enable selective coupling to thiols via Michael-type addition under mild, aqueous-compatible conditions. PROTAC assembly commonly uses thiol-bearing ligands or intermediates, with careful control of pH and thiol reactivity to minimize side reactions such as maleimide hydrolysis or thiol oxidation. Solvents are typically buffered aqueous media or compatible co-solvents, and inert handling is often used to preserve thiol integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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