Bis-PEG14-acid
Cat No.: BP-501967
4.5 
Bis-PEG14-acid is a bifunctional polyethylene glycol linker bearing two PEG arms terminated with carboxylic acid groups. Its extended, flexible PEG chain length and dual-ended architecture provide a hydrophilic spacer that can reduce steric interference and improve solubility when assembling PROTAC constructs. In targeted protein degradation designs, this type of linker serves as a conjugation scaffold that spatially positions two ligands (typically an E3 ligase binder and a target protein binder) to enable productive ternary complex formation. The carboxylate termini allow straightforward coupling to amine- or hydroxyl-containing handles on partner molecules via standard amide or ester-forming chemistries, facilitating modular synthesis and systematic optimization of linker length and geometry. Such bis-PEG linkers are valuable for researchers aiming to tune degradation potency and selectivity by controlling linker-mediated distance, conformational freedom, and overall physicochemical properties of the final PROTAC.
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* For research and manufacturing use only. Not for human or clinical use.
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Bis-PEG14-acid is a polyethylene glycol-based bifunctional linker designed for assembling PROTAC constructs that require controlled spacing and enhanced solubility between an E3 ligase ligand and a target-binding warhead. Its flexible PEG architecture can improve productive ternary complex formation by reducing steric constraints, while the terminal acid functionality enables reliable conjugation strategies. The detailed structural and synthetic considerations are provided below.
Structure: Bis-PEG14-acid is a bis-functional PEG linker featuring an extended, flexible polyether chain with terminal carboxylic acid groups. The structure contains ether linkages along the PEG backbone and carbonyl-containing acid termini, providing hydrophilicity and conformational flexibility suitable for PROTAC assembly.
Reactivity: The terminal carboxylic acids are typically used for amide bond formation with appropriately functionalized ligands (for example, amines) via standard coupling chemistries. Suitable approaches include carbodiimide-mediated coupling with an activating additive, or conversion to an activated ester followed by nucleophilic substitution. Reactions are commonly performed in polar aprotic solvents under conditions that preserve sensitive binding motifs, with pH control to balance activation and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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